Marfan syndrome is a dominant genetic disorder caused by a mutation in the fibrillin gene which affects the formation of microfibrils that provide strength to connective tissue. Those with Marfan syndrome are typically tall and thin with long arms and very flexible joints, thin stretchy blood vessels (that can burst), and often, an unnatural curvature of the spine. Assume the fibrillin gene has 2 alleles with F dominant to f . In addition, having two copies of the Fallele is fatal before or shortly after birth. If two parents who both have Marfan syndrome have two children that survive into adulthood, one with Marfan syndrome and one without, what are the genotypes of the two children? Explain your answer and make it clear which has the syndrome and which does not.
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